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Why Choose This Product?
- Double Strength Formula – Each tablet delivers 400 mg of SAM-e for effective mood, joint, and liver support.
- Superior Absorption – Enteric-coated tablets protect the active ingredient from stomach acid, ensuring better tolerance and bioavailability.
- Clinically Researched – Backed by studies showing benefits for emotional well-being, joint comfort, and liver health.
- Trusted Brand – Doctor’s Best is known for science-based nutrition and high-quality supplements.
- Clean & Safe – Vegan, gluten-free, and soy-free, with no artificial additives.

Product Overview
Doctor’s Best SAM-e Double Strength 400 mg delivers a clinically studied form of S-Adenosylmethionine (SAM-e) in easy-to-swallow enteric-coated tablets. Each serving provides 400 mg of active SAM-e, designed to support mood, joint comfort, and liver health. The enteric coating helps protect the delicate SAM-e from stomach acid and ensures optimal absorption in the intestines.
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Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
Free shipping on orders over $65
2 pcs 10% off
3 pcs 15% off
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How to use

Suggested Use: Take 1 tablet daily, preferably on an empty stomach or as recommended by a healthcare professional.

Important: Do not chew or crush tablets. Swallow whole to preserve the enteric coating.

Storage: Keep in a cool, dry place. Keep out of reach of children.
Comparison table
Double Strength 400 mg – Higher potency per tablet for maximum supportEnteric-Coated – Gentle on the stomach, designed for better absorptionMood Support – Helps maintain a positive outlook and emotional balance Joint Comfort – Promotes flexibility and cartilage healthLiver Health – Supports detoxification and healthy metabolismClean Formula – Vegan, gluten-free, soy-free, non-GMO
  | doctorsbest | Others |
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Double strength, 400 mg per tablet |
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Enteric-coated for maximum bioavailability |
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Mood balance, joint comfort, liver support |
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Backed by multiple studies on SAM-e |
FQA
What is SAM-e?
What is SAM-e?
SAM-e (S-Adenosylmethionine) is a compound naturally produced in the body that supports mood, joint health, and liver function.
How should I take this product?
How should I take this product?
Take 1 enteric-coated tablet daily on an empty stomach, or as recommended by your healthcare professional. Swallow whole—do not chew or crush.
How long does it take to notice benefits?
How long does it take to notice benefits?
Results vary, but many users experience improvements in mood and joint comfort within a few weeks of consistent use.
Is it safe to take long-term?
Is it safe to take long-term?
Yes, SAM-e can be used long-term under professional guidance. Regular check-ins with your healthcare provider are recommended.
Who should avoid taking SAM-e?
Who should avoid taking SAM-e?
Pregnant or nursing women, and those taking antidepressants (SSRIs, MAOIs) or with certain medical conditions, should consult a doctor before use.